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When NFL betting players think of current rivalries in the league, Indianapolis-New England has to come to mind, and the two AFC powers will clash once again, this time in Foxborough. Both are coming off wins over AFC North opponents, and a victory this week would be a statement to the rest of the conference.

Colts Patriots Betting – Sunday, November 21st, 4:15 PM ET

For a change, the Colts’ (6-3) offense didn’t have to do much as the defense took over in a 23-17 win over Cincinnati to remain unbeaten at home. The Colts forced five turnovers, returning one for a touchdown, but football betting players still don’t know which defense is going to show up for Indy from week to week. Peyton Manning was 20-of-36 for 185 yards, and the Colts’ offense seemed perfectly content to let the Bengals beat themselves. You can look for them to come out strong on the road in New England, however.

You know one of those games where you can tell early on that a team is going to win? It was like that for the Patriots (7-2), who went into Pittsburgh and rolled the Steelers 39-26 in a game that wasn’t even that close. Tom Brady was 30-of-43 for 350 yards and three games, and he also ran one in for a score that he ended with an emphatic spike of the ball. The Patriots, and Brady in particular, always get up to play in Pittsburgh, but you have to wonder if that took everything out of them. Back-to-back games against the likes of Pittsburgh and Indianapolis is nothing to sneeze at.

Even those who check out NBA scores will be tuning into this game, in which the Patriots are a 3.5-point favorite at home. The two have split their last 10 meetings SU, and the Patriots hold a slight 5-4-1 edge ATS. Also, half of the games have gone over the posted total, so there isn’t much between these two at all. The last four meetings have come in Indianapolis, but the Patriots are only 3-2 SU in Indy’s last five trips to New England.

We’re picking the Colts for the “upset” on the grounds that the Patriots had a massive game last week, and they could have a little bit of a letdown this week, whether they want to or not. Meanwhile, it was almost like the Indy offense had the week off, and we know that the New England defense can be sketchy, especially the secondary, and that plays right into the Colts’ hands. Indy’s defense isn’t that great, either, but they’ll be buoyed by a big performance last weekend. Place a sports bet on Indy on Sunday.

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